ea0011p497 | Endocrine tumours and neoplasia | ECE2006
Fratticci A
, Padronetti R
, Giangaspero F
, Ventura L
, Piccirilli M
, Esposito V
, Gulino A
, Alesse E
, Jaffrain-Rea ML
The beta-HLH transcription factors NeuroD1 and ASH1 are frequently expressed by pituitary adenomas, both being present in all corticotroph, most clinically non-secreting (CNS) and a subset of GH and/or PRL-secreting adenomas. We wished to investigate the expression of the related beta-HLH factors neurogenins (Ngn) 1, 2 and 3 in the pituitary (n=4) and in a series of pituitary adenomas (n=45). RT-PCR was performed at different amplification cycles (up to 45) in al...